February 1982
Volume 22, Issue 2
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Articles  |   February 1982
Ca++-induced cataract.
Investigative Ophthalmology & Visual Science February 1982, Vol.22, 263-267. doi:https://doi.org/
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      K R Hightower, V N Reddy; Ca++-induced cataract.. Invest. Ophthalmol. Vis. Sci. 1982;22(2):263-267. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Cataracts in cultured rabbit lenses were produced by elevation of internal calcium. Experimental procedures were successful in increasing levels of total and bound Ca++, often without significant changes in sodium, potassium, or water content. Although the excess in calcium was predominantly associated with water-soluble proteins and was freely diffusible, a significant amount was bound to membranes and cytosol water-insoluble proteins. Thus, in lenses with a 10-fold increase in total Ca++, the bound Ca++ increased twofold, nearly 35% of which remained fixed to water-insoluble and membrane proteins after exhaustive (72 hr) dialysis. In contrast, over 95% of the Ca++ in water-soluble protein fractions was removed by dialysis.

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