October 1982
Volume 23, Issue 4
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Articles  |   October 1982
The effects of methylprednisolone acetate on macromolecular synthesis and glucose oxidation in epithelial cells of the ocular surface.
Investigative Ophthalmology & Visual Science October 1982, Vol.23, 501-506. doi:
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      W J O'Brien, D H Geroski; The effects of methylprednisolone acetate on macromolecular synthesis and glucose oxidation in epithelial cells of the ocular surface.. Invest. Ophthalmol. Vis. Sci. 1982;23(4):501-506.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Epithelial cells that re-epithelialized corneas after the normal corneal epithelium was removed limbus to limbus by scraping were found to be metabolically responsive to methylprednisolone acetate. Seventy-two hours after scraping, the re-epithelializing cells from steroid-treated animals were found to have a 26% slower rate of DNA synthesis, a 30% slower rate of glucose oxidation via glycolysis, and a 79% greater rate of RNA synthesis with no apparent change in gross protein synthesis as compared with vehicle-treated controls. The DNA content of the epithelial layer isolated from steroid-treated corneas was reduced by 31% as compared with that of vehicle-treated controls.

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