March 1983
Volume 24, Issue 3
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Articles  |   March 1983
Effect of light on dopamine turnover and metabolism in rabbit retina.
Investigative Ophthalmology & Visual Science March 1983, Vol.24, 384-388. doi:
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      D Parkinson, R R Rando; Effect of light on dopamine turnover and metabolism in rabbit retina.. Invest. Ophthalmol. Vis. Sci. 1983;24(3):384-388.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Some neurochemical responses of dopaminergic neurons in the rabbit retina have been measured during prolonged light or dark adaptation. Light adaptation produced small increases (20%) in dopamine levels but larger increases (50-100%) in the two metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid. Light also significantly increased tyrosine hydroxylase activity; the increase was more pronounced when activity was measured in vivo than in vitro. Dopamine turnover, was faster in the light than in the dark. All these data support the suggestion that light leads to the activation of dopaminergic neurons in the rabbit retina.

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