December 1982
Volume 23, Issue 6
Articles  |   December 1982
Aqueous immune complexes in immunogenic uveitis.
Investigative Ophthalmology & Visual Science December 1982, Vol.23, 715-718. doi:
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      E L Howes, D H Char, M Christensen; Aqueous immune complexes in immunogenic uveitis.. Invest. Ophthalmol. Vis. Sci. 1982;23(6):715-718. doi:

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A primary immunogenic uveitis was produced in rabbits by the intravitreal injection of bovine plasma albumin or ovalbumin. A secondary or recurrent uveitis was induced by intravenous injection of the specific soluble antigen several months after the cessation of primary inflammation. Aqueous antigen-antibody complexes were studied at times of maximal clinical response in both primary and recurrent forms during resolution of primary immunogenic uveitis, and in a nonspecific protein extravasation induced by aqueous paracentesis. Immune complexes could be demonstrated only during times of clinically evident inflammation in immunogenic uveitis. The results indicate the importance of antigen-antibody complex formation in the pathogenesis of this form of experimental ocular inflammatory disease.


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