December 1982
Volume 23, Issue 6
Articles  |   December 1982
Changes in rabbit lacrimal gland fluid osmolarity with flow rate.
Investigative Ophthalmology & Visual Science December 1982, Vol.23, 804-806. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J P Gilbard, D A Dartt; Changes in rabbit lacrimal gland fluid osmolarity with flow rate.. Invest. Ophthalmol. Vis. Sci. 1982;23(6):804-806. doi:

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

To determine whether the osmolarity of rabbit lacrimal gland fluid (LGF) changes with flow rate, microvolumes (approximately 0.2 microliters) were collected directly from he cannulated glandular excretory duct of anesthetized rabbits. Low flow rates were obtained by collection of LGF 5 min after instillation of proparacaine: higher flow rates were obtained by stimulation with 0.45, 0.9, 3.8, or 15 micrograms of acetylcholine administered by local arterial injection. At low flow rates (less than 0.11 microliters/min), LGF osmolarity was 334 +/- 4 mOsm/L (n = 19). As flow rate increased to maximal rates (13.0 to 19.1 microliters/min), LGF osmolarity decreased to a value of 299 +/- 2 mOsm/L (n = 7). In keratoconjunctivitis sicca, increase in LGF osmolarity, as well as tear film evaporation, may contribute to elevated tear film osmolarity.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.