May 1983
Volume 24, Issue 5
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Articles  |   May 1983
An animal model of trachoma: IV. The failure of local immunosuppression to reveal inapparent infection.
Investigative Ophthalmology & Visual Science May 1983, Vol.24, 647-650. doi:
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      H R Taylor, S L Johnson, J Schachter, R A Prendergast; An animal model of trachoma: IV. The failure of local immunosuppression to reveal inapparent infection.. Invest. Ophthalmol. Vis. Sci. 1983;24(5):647-650.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Repeated inoculation with live chlamydia trachomatis is necessary to develop a model of trachoma in monkeys. However, it is not possible to reisolate chlamydia from the monkey's eye after the first 1 or 2 months of weekly reinoculation. The effect of subconjunctival steroid injections in monkeys that had received weekly inoculations with live chlamydia is reported. Despite a profound suppression of local inflammation, steroid treatment did not produce a reactivation of identifiable chlamydial infection as determined by repeated chlamydial cultures and cytologic examinations.

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