October 1984
Volume 25, Issue 10
Articles  |   October 1984
Immunohistochemical evidence for preproenkephalin A synthesis in human retinoblastoma.
Investigative Ophthalmology & Visual Science October 1984, Vol.25, 1210-1212. doi:
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      A Tarkkanen, T Tervo, K Tervo, P Panula; Immunohistochemical evidence for preproenkephalin A synthesis in human retinoblastoma.. Invest. Ophthalmol. Vis. Sci. 1984;25(10):1210-1212.

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      © ARVO (1962-2015); The Authors (2016-present)

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Human retinoblastoma contains clusters of cells immunoreactive for methionine-enkephalin and methionine-enkephalin-arginine-phenylalanine. Some tumour cells also exhibited methionine-enkephalin-arginine-glycine-leucine-like immunoreactivity. The results are in agreement with those obtained with similar testing of neuroblastoma cell cultures. It is concluded that some human retinoblastoma cells are capable of synthesizing preproenkephalin A or parts of this molecule.


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