February 1984
Volume 25, Issue 2
Articles  |   February 1984
Human anterior uvea synthesizes lipoxygenase products from arachidonic acid.
Investigative Ophthalmology & Visual Science February 1984, Vol.25, 221-223. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P S Kulkarni, A V Rodriguez, B D Srinivasan; Human anterior uvea synthesizes lipoxygenase products from arachidonic acid.. Invest. Ophthalmol. Vis. Sci. 1984;25(2):221-223.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Arachidonic acid is metabolized into biologically active prostaglandins, thromboxanes, and lipoxygenase products, leukotrienes. In the present study, the ability of human anterior uvea to synthesize lipoxygenase products from 14C-radiolabelled arachidonic acid is assessed. Following cyclooxygenase inhibition by indomethacin, human anterior uvea, similar to rabbit conjunctiva and anterior uvea, synthesizes chemotactic products 12-hydroxyeicosatetraenoic acid (HETE) and 5,12-DiHETE, indicating the presence of both 5- and 12-lipoxygenase enzyme activities.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.