February 1984
Volume 25, Issue 2
Articles  |   February 1984
Human anterior uvea synthesizes lipoxygenase products from arachidonic acid.
Investigative Ophthalmology & Visual Science February 1984, Vol.25, 221-223. doi:
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      P S Kulkarni, A V Rodriguez, B D Srinivasan; Human anterior uvea synthesizes lipoxygenase products from arachidonic acid.. Invest. Ophthalmol. Vis. Sci. 1984;25(2):221-223.

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      © ARVO (1962-2015); The Authors (2016-present)

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Arachidonic acid is metabolized into biologically active prostaglandins, thromboxanes, and lipoxygenase products, leukotrienes. In the present study, the ability of human anterior uvea to synthesize lipoxygenase products from 14C-radiolabelled arachidonic acid is assessed. Following cyclooxygenase inhibition by indomethacin, human anterior uvea, similar to rabbit conjunctiva and anterior uvea, synthesizes chemotactic products 12-hydroxyeicosatetraenoic acid (HETE) and 5,12-DiHETE, indicating the presence of both 5- and 12-lipoxygenase enzyme activities.


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