July 1984
Volume 25, Issue 7
Articles  |   July 1984
Activated complement in inflamed aqueous humor.
Investigative Ophthalmology & Visual Science July 1984, Vol.25, 871-873. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      B J Mondino, M M Glovsky, L Ghekiere; Activated complement in inflamed aqueous humor.. Invest. Ophthalmol. Vis. Sci. 1984;25(7):871-873.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Activated complement is an important mediator of inflammation. Radioimmunoassay was used to measure levels of C3a, an activated fragment of C3, in aqueous humor. Additionally, immunoelectrophoresis was performed on aqueous humor to detect Factor B and its conversion product, Bb, as well as C3c, a breakdown product of C3. All six samples of normal aqueous humor had no detectable C3a, C3c, or Factor B. All eight samples of aqueous humor from patients with anterior uveitis had measurable levels of C3a. Factor B and C3c were detected in 3/7 samples of inflamed aqueous humor. Factor B was converted fully to Bb in two of these three samples, suggesting alternative pathway activation of complement. Activated complement fragments are present in the aqueous humor of eyes with anterior uveitis and may help mediate the inflammatory process.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.