January 1985
Volume 26, Issue 1
Free
Articles  |   January 1985
Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine.
Investigative Ophthalmology & Visual Science January 1985, Vol.26, 45-49. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P C Maudgal, A M Verbruggen, E De Clercq, R Busson, R Bernaerts, M de Roo, C Ameye, L Missotten; Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine.. Invest. Ophthalmol. Vis. Sci. 1985;26(1):45-49.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Following topical application of (125)IVDU, the radiolabeled analogue of bromovinyldeoxyuridine ([E]-5-[2-bromovinyl]-2'-deoxyuridine), as 0.5% or 0.3% eyedrops, to rabbits, (125I)IVDU appeared in the anterior chamber fluid at drug levels well above the minimum concentration (0.01 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. These findings are consistent with the efficacy of 0.5% bromovinyldeoxyuridine eyedrops in the topical treatment of herpes simplex uveitis.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×