January 1985
Volume 26, Issue 1
Articles  |   January 1985
Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine.
Investigative Ophthalmology & Visual Science January 1985, Vol.26, 45-49. doi:
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      P C Maudgal, A M Verbruggen, E De Clercq, R Busson, R Bernaerts, M de Roo, C Ameye, L Missotten; Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine.. Invest. Ophthalmol. Vis. Sci. 1985;26(1):45-49.

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      © ARVO (1962-2015); The Authors (2016-present)

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Following topical application of (125)IVDU, the radiolabeled analogue of bromovinyldeoxyuridine ([E]-5-[2-bromovinyl]-2'-deoxyuridine), as 0.5% or 0.3% eyedrops, to rabbits, (125I)IVDU appeared in the anterior chamber fluid at drug levels well above the minimum concentration (0.01 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. These findings are consistent with the efficacy of 0.5% bromovinyldeoxyuridine eyedrops in the topical treatment of herpes simplex uveitis.


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