September 1984
Volume 25, Issue 9
Articles  |   September 1984
Choroidal microvascular repair after argon laser photocoagulation. Ultrastructural observations.
Investigative Ophthalmology & Visual Science September 1984, Vol.25, 1019-1026. doi:
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      D D Perry, R L Reddick, J M Risco; Choroidal microvascular repair after argon laser photocoagulation. Ultrastructural observations.. Invest. Ophthalmol. Vis. Sci. 1984;25(9):1019-1026.

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      © ARVO (1962-2015); The Authors (2016-present)

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Acute laser injury to the tapetum of the feline retina produces thrombosis of the choriocapillaris. Early changes are characterized by the appearance of platelet-fibrin thrombi within capillary loops and disruption of endothelial integrity. By 4 days, thrombi have disappeared, and the endothelium shows regenerative changes. No endothelial cell mitotic activity is seen. The endothelial cytoplasm becomes plump, and there is a loss of the fenestrations adjacent to Bruch's membrane. By 10-20 days, the capillary structure shows gradual restoration. At 30 days, endothelial cell fenestrae are clearly evident adjacent to Bruch's membrane. The reparative process in this model appears to evolve as a result of thrombolysis and endothelial cell activation.


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