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J Sugar, M Nyberg, J Bernstein, A Barlow, W Slater; Imipramine inhibiton of ragweed allergic conjunctivitis.. Invest. Ophthalmol. Vis. Sci. 1984;25(2):217-218.
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Twenty-seven patients sensitive to ragweed pollen were treated with topical imipramine 0.05% in one eye and vehicle in the other in a double-masked fashion. The eyes treated with imipramine showed significantly less redness, tearing, and discomfort after exposure to pollen extract. Imipramine, a tricyclic antidepressant, appears to be an effective antihistamine in the eye.
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