July 1984
Volume 25, Issue 7
Articles  |   July 1984
Conjunctival epithelial wound healing.
Investigative Ophthalmology & Visual Science July 1984, Vol.25, 860-863. doi:
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      H S Geggel, J Friend, R A Thoft; Conjunctival epithelial wound healing.. Invest. Ophthalmol. Vis. Sci. 1984;25(7):860-863.

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      © ARVO (1962-2015); The Authors (2016-present)

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In vivo conjunctival epithelial healing in albino rabbits was investigated by light microscopy following both n-heptanol and trephined conjunctival wounding. Reepithelialization occurred faster following n-heptanol treatment (3 days) versus trephination (6-7 days). No goblet cells were present in the migrating epithelium during reepithelialization. After 1 day of wounding, goblet cells disappeared several millimeters peripheral to the wound margin in both types of wounds. Goblet cells first reappeared peripherally 1 week after wounding before they appeared in the central wound area. These observations indicate that a large area of conjunctival epithelium surrounding a wound is involved with repair of that wound. Since the goblet cell content of conjunctival epithelium appears to change as a result of the stresses of epithelial repair, the goblet cell population may reflect the presence of reparative or proliferative processes in the ocular surface.


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