March 1985
Volume 26, Issue 3
Articles  |   March 1985
Hexitol production by canine retinal microvessels.
Investigative Ophthalmology & Visual Science March 1985, Vol.26, 382-384. doi:
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      T S Kern, R L Engerman; Hexitol production by canine retinal microvessels.. Invest. Ophthalmol. Vis. Sci. 1985;26(3):382-384.

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      © ARVO (1962-2015); The Authors (2016-present)

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Hexitol-producing activity has been quantitated in microvessels isolated from retina and cerebral cortex of dogs, a species known to develop a retinopathy similar to that seen in diabetic patients. Both the retinal and cerebral microvessels produce galactitol from galactose, but at a rate several-fold less than that seen in canine lens epithelium. This hexitol-producing activity of the microvessels is not an artifact of erythrocyte contamination and can be inhibited by the aldose reductase inhibitor, Sorbinil.


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