March 1985
Volume 26, Issue 3
Articles  |   March 1985
Light exposure can reduce selectively or abolish the C-wave of the albino rat electroretinogram.
Investigative Ophthalmology & Visual Science March 1985, Vol.26, 388-393. doi:
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      A L Graves, D G Green, L J Fisher; Light exposure can reduce selectively or abolish the C-wave of the albino rat electroretinogram.. Invest. Ophthalmol. Vis. Sci. 1985;26(3):388-393.

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      © ARVO (1962-2015); The Authors (2016-present)

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The ERG (electroretinogram) of the albino rat is reported to lack a c-wave. Observations of our own suggested that the conditions of light-rearing are important. Consequently, the authors recorded c-waves in two groups of albino rats. One group was reared from birth in dim illumination (dark-reared) and the other in 12/12 cyclic light (light-reared). Rats were tested after birth from 22 days to about 1 year. All dark-reared animals had a c-wave. Rats reared in cyclic light typically had no detectable c-wave. Physiologic and anatomic evidence suggests this consistent difference, c-waves present in dark-reared animals but absent or diminished in light-reared animals, is probably not due to extensive light induced retinal damage. No consistent differences between the two groups were seen in a- or b-wave thresholds, a- or b-wave intensity-response functions, and in the time-course of b-wave dark adaptation.


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