April 1985
Volume 26, Issue 4
Articles  |   April 1985
Effect of LTD4 on conjunctival vasopermeability and blood-aqueous barrier integrity.
Investigative Ophthalmology & Visual Science April 1985, Vol.26, 481-485. doi:
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      D F Woodward, S E Ledgard; Effect of LTD4 on conjunctival vasopermeability and blood-aqueous barrier integrity.. Invest. Ophthalmol. Vis. Sci. 1985;26(4):481-485.

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      © ARVO (1962-2015); The Authors (2016-present)

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The effect of leukotriene D4 (LTD4) on the microvascular permeability of selected ocular tissues of the guinea pig was evaluated quantitatively by utilizing 125I-albumin and 51Cr-erythrocytes. Topically applied LTD4 (1 ng-10 micrograms) produced a dose-related increase in conjunctival microvascular permeability. However, topical administration of such doses of LTD4 did not promote albumin leakage into the aqueous humor or iris-ciliary body. Intravitreal injection of graded doses of LTD4 also failed to increase the albumin content of the aqueous humor and iris-ciliary body. Thus, although LTD4 increased conjunctival microvascular permeability, it does not appear to disrupt the blood-aqueous barrier of the guinea pig eye.


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