May 1985
Volume 26, Issue 5
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Articles  |   May 1985
Biosynthesis of neopterin, sepiapterin, and biopterin in rat and human ocular tissues.
Investigative Ophthalmology & Visual Science May 1985, Vol.26, 768-770. doi:
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      G N Rao, E Cotlier; Biosynthesis of neopterin, sepiapterin, and biopterin in rat and human ocular tissues.. Invest. Ophthalmol. Vis. Sci. 1985;26(5):768-770.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Neopterin, sepiapterin, and biopterin synthesis by lens, retina, and ciliary body-iris of rat and human indicates pteridine formation from their precursor, GTP. The pteridine biosynthesis was higher in the retina (neopterin 422 +/- 27, 260 +/- 24; sepiapterin 135 +/- 12, 118 +/- 14; biopterin 76 +/- 10, 68 +/- 8 nanomoles/g soluble protein/hr, in rat and human, respectively) than in the ciliary body-iris and lens. The light-sensitive pteridines may protect eye tissues against the effects of sunlight in addition to their role in the hydroxylation of aromatic amino acids.

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