May 1985
Volume 26, Issue 5
Articles  |   May 1985
Folding of photoreceptor cell layer: a new form of retinal lesion in rat.
Investigative Ophthalmology & Visual Science May 1985, Vol.26, 771-774. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      V L Lai, M W Rana; Folding of photoreceptor cell layer: a new form of retinal lesion in rat.. Invest. Ophthalmol. Vis. Sci. 1985;26(5):771-774.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

A new form of retinal lesion has been observed in rats. It is characterized by inward folding of the photoreceptor cell layer (outer nuclear layers); microretinal detachment; thinning of inner retinal layer; loss of Muller cells in the lesion; in most cases, normal retinal surface contour, and no increase in total retinal thickness. Remarkable strain differences were noted. In Sprague-Dawley rats, the incidence increases with age, and lesions are more often located in the peripheral one third. On the other hand, in rat strains having known hereditary retinal disorders (Wag/Rij and Wag/Long-Evans), the incidence of lesions decreases with increasing age of observed specimens, and the lesions are more frequently located in the posterior one third. These new forms of retinal lesions differ from retinal folds found in the far periphery of the developing retina. Our findings suggest that loss of Muller cells in the lesions initiates this disorder.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.