October 1986
Volume 27, Issue 10
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Articles  |   October 1986
Ocular penetration and efficacy of chloroethyldeoxyuridine against herpetic keratouveitis.
Investigative Ophthalmology & Visual Science October 1986, Vol.27, 1453-1458. doi:
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      P C Maudgal, E De Clercq, R Bernaerts, M Dieltiens, M Breemersch, L Van Eeckhoutte; Ocular penetration and efficacy of chloroethyldeoxyuridine against herpetic keratouveitis.. Invest. Ophthalmol. Vis. Sci. 1986;27(10):1453-1458.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Topical administration of 0.1% or 1% chloroethyldeoxyuridine eyedrops caused a significant reduction in the severity of experimental herpes simplex iritis and stromal keratitis in rabbits. The healing effect caused by chloroethyldeoxyuridine was comparable to that obtained with 0.1% and 0.5% bromovinylde-oxyuridine eyedrops. The drug levels achieved in the anterior chamber fluid following topical application of 1% eyedrops of [2-14C]CEDU, a radiolabelled analogue of chloroethyldeoxyuridine, were well above the minimum concentration (0.1 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. The beneficial effects of chloroethyldeoxyuridine on stomal keratitis and iritis appear consistent with its efficient penetration through the cornea.

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