August 1986
Volume 27, Issue 8
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Articles  |   August 1986
Epithelial ion transport in rabbit corneas following myopic keratomileusis.
Investigative Ophthalmology & Visual Science August 1986, Vol.27, 1277-1280. doi:
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      C A Swinger, O A Candia, S Marcus, B A Barker, E W Kornmehl; Epithelial ion transport in rabbit corneas following myopic keratomileusis.. Invest. Ophthalmol. Vis. Sci. 1986;27(8):1277-1280.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

In isolated rabbit corneas that had undergone lamellar keratectomy or myopic keratomileusis, the stimulation of chloride transport by 10(-5) M epinephrine was completely inhibited at 1 week following surgery. At 28 days following surgery, both groups responded to 10(-7) M epinephrine. The response to 10(-5) M amphotericin B was normal both at 1 week and at 28 days following surgery. We conclude that, although the Na-K pump was not affected by the lamellar keratectomy and cryolathing, that either the epithelial beta receptors and/or the cAMP pathway were temporarily inhibited for at least 1 week following surgery. A lamellar keratectomy, therefore, can have an adverse effect on the epithelial transport system of the corneal epithelium even though the epithelium may appear normal clinically.

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