December 1986
Volume 27, Issue 12
Articles  |   December 1986
Dexamethasone, D-penicillamine, and glaucoma filter surgery in rabbits.
Investigative Ophthalmology & Visual Science December 1986, Vol.27, 1755-1757. doi:
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      L J McGuigan, D J Cook, M E Yablonski; Dexamethasone, D-penicillamine, and glaucoma filter surgery in rabbits.. Invest. Ophthalmol. Vis. Sci. 1986;27(12):1755-1757.

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      © ARVO (1962-2015); The Authors (2016-present)

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A study was made in rabbits of the effect of topical dexamethasone ointment, .05%, and either subconjunctival or intraperitoneal D-penicillamine on the duration of function of glaucoma filtering surgery. The drugs were tested alone and in combination. Intraperitoneal D-penicillamine was not effective, either alone or combined with topical dexamethasone. Topical dexamethasone ointment alone and subconjunctival D-penicillamine alone significantly prolonged the duration of function of the filter surgery; however, when combined, no additional effect was observed. It was concluded that the institution of therapy with both drugs immediately after glaucoma filtering surgery was not the optimal temporal sequence for combining the two modes of therapy.


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