November 1986
Volume 27, Issue 11
Articles  |   November 1986
Anatomy of the mouse retina. Capillary basement membrane thickness.
Investigative Ophthalmology & Visual Science November 1986, Vol.27, 1653-1658. doi:
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      R A Cuthbertson, T E Mandel; Anatomy of the mouse retina. Capillary basement membrane thickness.. Invest. Ophthalmol. Vis. Sci. 1986;27(11):1653-1658.

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      © ARVO (1962-2015); The Authors (2016-present)

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Transmission electron microscopy of ultrathin sections was used to measure mouse retinal capillary basement membrane thickness (BMT). BMT increases predictably with age from 50 +/- 9 nm at 6 weeks to 154 +/- 27 nm at 20 months, but is not affected by strain or sex. There is an effect of retinal site, however, with BMT increasing with the radial distance from the optic nerve, 41 +/- 4 nm (center), 54 +/- 5 nm (mid-zone), and 64 +/- 6 nm (periphery). The layer of retina from which capillaries were taken had no effect on BMT, and the inner and outer BMT maintained a consistent ratio, even at different ages.


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