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A L Southren, M R Hernandez, D l'Hommedieu, G G Gordon, B I Weinstein; Potentiation of collagen synthesis in explants of the rabbit eye by 5 beta-dihydrocortisol.. Invest. Ophthalmol. Vis. Sci. 1986;27(12):1757-1760.
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The biologic effect of 5 beta-dihydrocortisol on collagen synthesis was evaluated. The metabolite was found to potentiate subthreshold levels of dexamethasone in increasing 3H-proline incorporation in cells of the outflow region of the rabbit. Digestion of the tissue with highly purified collagenase indicated that the 3H-proline was incorporated into collagen type protein. This study demonstrates another biologic activity of 5 beta-dihydrocortisol, a metabolite found to accumulate in cells cultured from trabeculectomy specimens from patients with primary open angle glaucoma.
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