December 1986
Volume 27, Issue 12
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Articles  |   December 1986
Potentiation of collagen synthesis in explants of the rabbit eye by 5 beta-dihydrocortisol.
Investigative Ophthalmology & Visual Science December 1986, Vol.27, 1757-1760. doi:
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      A L Southren, M R Hernandez, D l'Hommedieu, G G Gordon, B I Weinstein; Potentiation of collagen synthesis in explants of the rabbit eye by 5 beta-dihydrocortisol.. Invest. Ophthalmol. Vis. Sci. 1986;27(12):1757-1760.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The biologic effect of 5 beta-dihydrocortisol on collagen synthesis was evaluated. The metabolite was found to potentiate subthreshold levels of dexamethasone in increasing 3H-proline incorporation in cells of the outflow region of the rabbit. Digestion of the tissue with highly purified collagenase indicated that the 3H-proline was incorporated into collagen type protein. This study demonstrates another biologic activity of 5 beta-dihydrocortisol, a metabolite found to accumulate in cells cultured from trabeculectomy specimens from patients with primary open angle glaucoma.

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