August 1986
Volume 27, Issue 8
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Articles  |   August 1986
Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein.
Investigative Ophthalmology & Visual Science August 1986, Vol.27, 1296-1300. doi:
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      I Gery, B Wiggert, T M Redmond, T Kuwabara, M A Crawford, B P Vistica, G J Chader; Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein.. Invest. Ophthalmol. Vis. Sci. 1986;27(8):1296-1300.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Rats immunized with microgram amounts of interphotoreceptor retinoid-binding protein (IRBP), a glycoprotein which localizes specifically in the eye and pineal gland, developed uveoretinitis and pinealitis. The severity and onset of changes were found to be dose-related and to be enhanced by B. pertussis bacteria. In general, the inflammatory changes induced by IRBP resembled those provoked by S-antigen (S-Ag), but significant differences were noted between the two diseases. The possible usefulness of the new experimental autoimmune disease is discussed.

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