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I Gery, B Wiggert, T M Redmond, T Kuwabara, M A Crawford, B P Vistica, G J Chader; Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein.. Invest. Ophthalmol. Vis. Sci. 1986;27(8):1296-1300.
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Rats immunized with microgram amounts of interphotoreceptor retinoid-binding protein (IRBP), a glycoprotein which localizes specifically in the eye and pineal gland, developed uveoretinitis and pinealitis. The severity and onset of changes were found to be dose-related and to be enhanced by B. pertussis bacteria. In general, the inflammatory changes induced by IRBP resembled those provoked by S-antigen (S-Ag), but significant differences were noted between the two diseases. The possible usefulness of the new experimental autoimmune disease is discussed.
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