January 1987
Volume 28, Issue 1
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Articles  |   January 1987
Rod ERGs in retinitis pigmentosa and cone-rod degeneration.
Investigative Ophthalmology & Visual Science January 1987, Vol.28, 140-150. doi:
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      D G Birch, G E Fish; Rod ERGs in retinitis pigmentosa and cone-rod degeneration.. Invest. Ophthalmol. Vis. Sci. 1987;28(1):140-150.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Rod amplitudes as a function of retinal illuminance were analyzed by determining the parameters of the best fit Naka-Rushton function for 15 normal subjects, 25 patients with rod-cone degeneration, and 10 patients with cone-rod degeneration. Rod b-wave implicit times were analyzed by determining the best linear fit to log retinal illuminance. Retinal illuminances necessary for a criterion b-wave implicit time and for a half-maximum amplitude response (log k) were highly correlated indices of rod sensitivity. Both measures were normal or near normal in patients of all ages with cone-rod degeneration, but significantly elevated in patients with rod-cone degeneration. These results suggest that the underlying mechanisms of rod degeneration are fundamentally different in these two forms of hereditary retinal degeneration.

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