April 1987
Volume 28, Issue 4
Articles  |   April 1987
The response of retinal vasculature to angiotensin.
Investigative Ophthalmology & Visual Science April 1987, Vol.28, 676-682. doi:
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      E J Rockwood, F Fantes, E B Davis, D R Anderson; The response of retinal vasculature to angiotensin.. Invest. Ophthalmol. Vis. Sci. 1987;28(4):676-682.

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      © ARVO (1962-2015); The Authors (2016-present)

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A retinal arterial constriction was produced in anesthetized cats with a continuous transvitreal infusion of angiotensin I or angiotensin II (Ile-5). Constriction of vessels near the infusion cannula tip occurred over a range of angiotensin II concentrations from 10(-9) to 10(-4) molar, and was reversibly blocked by a ten-fold excess of the competitive antagonist saralasin. Constriction did not occur in response to angiotensin I if angiotensin-converting enzyme was blocked with Captopril. Control infusions of saline did not elicit a contraction of the retinal arteries. Severe axonal and inner retinal damage and necrosis occurred when angiotensin II produced a prolonged vasospasm, but not after infusion with control solutions, or when-constriction caused by angiotensin was brief.


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