November 1988
Volume 29, Issue 11
Free
Articles  |   November 1988
The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery.
Author Affiliations
  • D A Lee
    Jules Stein Eye Institute, UCLA School of Medicine 90024-1771.
  • K W Leong
    Jules Stein Eye Institute, UCLA School of Medicine 90024-1771.
  • W C Panek
    Jules Stein Eye Institute, UCLA School of Medicine 90024-1771.
  • C T Eng
    Jules Stein Eye Institute, UCLA School of Medicine 90024-1771.
  • B J Glasgow
    Jules Stein Eye Institute, UCLA School of Medicine 90024-1771.
Investigative Ophthalmology & Visual Science November 1988, Vol.29, 1692-1697. doi:
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    • Get Citation

      D A Lee, K W Leong, W C Panek, C T Eng, B J Glasgow; The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery.. Invest. Ophthalmol. Vis. Sci. 1988;29(11):1692-1697.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A study was performed to examine the effect of a localized and sustained delivery of 5-fluorouracil (5-FU) on the success of glaucoma filtration surgery in 18 rabbits in a prospective, randomized, double-masked and placebo-controlled fashion. A bioerodible polyanhydride composed of bis (p-carboxyphenoxy) propane and sebacic acid was used as the drug carrier. The polymer and 5-FU (20% by weight) were compressed into 3 mm diameter discs, 1 mm thick. The polymer with the 5-FU was randomized to one eye and the fellow eye received the blank polymer. The results showed that intraocular pressures (IOP) were lower in the experimental eyes during the 5th through 17th postoperative days, but eventually both experimental and control eyes returned to preoperative levels. Filtration blebs lasted longer in experimental eyes when compared to control eyes. Implant disappearance occurred after IOP elevations and bleb failure. Eventually, the filtration surgery failed in both the experimental and control rabbit eyes.

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