November 1988
Volume 29, Issue 11
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Articles  |   November 1988
Volume flow across the isolated retinal pigment epithelium of cynomolgus monkey eyes.
Author Affiliations
  • S Tsuboi
    Department of Ophthalmology, University of Minnesota, Minneapolis.
  • J E Pederson
    Department of Ophthalmology, University of Minnesota, Minneapolis.
Investigative Ophthalmology & Visual Science November 1988, Vol.29, 1652-1655. doi:
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      S Tsuboi, J E Pederson; Volume flow across the isolated retinal pigment epithelium of cynomolgus monkey eyes.. Invest. Ophthalmol. Vis. Sci. 1988;29(11):1652-1655.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The retinal pigment epithelium (RPE)-choroid was isolated from cynomolgus monkey eyes with experimental retinal detachments and the volume flow was determined in vitro using Ussing-type chambers. With zero pressure difference across the membrane, retina-to-choroid volume flow was 5.0 microliter/hr/cm2 in eyes with subacute retinal detachments (1-2 weeks). In eyes with chronic retinal detachment (8-20 months), the flow was 7.3 microliter/hr/cm2. Volume flow was not affected by the elimination of ambient bicarbonate. Transepithelial potential difference and resistance were 8.9 mV, retinal side positive, and 339 ohm-cm2, respectively, in chronic retinal detachments. It is concluded that there is a posteriorly directed flow of fluid across the RPE in cynomolgus monkey eyes with chronic retinal detachments.

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