February 1988
Volume 29, Issue 2
Free
Articles  |   February 1988
The effect of sodium hyaluronate on the corneal epithelium. An ultrastructural study.
Author Affiliations
  • Y S Wysenbeek
    Department of Ophthalmology, Beilinson Medical Center, Petah Tikva, Israel.
  • N Loya
    Department of Ophthalmology, Beilinson Medical Center, Petah Tikva, Israel.
  • I Ben Sira
    Department of Ophthalmology, Beilinson Medical Center, Petah Tikva, Israel.
  • I Ophir
    Department of Ophthalmology, Beilinson Medical Center, Petah Tikva, Israel.
  • Y Ben Shaul
    Department of Ophthalmology, Beilinson Medical Center, Petah Tikva, Israel.
Investigative Ophthalmology & Visual Science February 1988, Vol.29, 194-199. doi:
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    • Get Citation

      Y S Wysenbeek, N Loya, I Ben Sira, I Ophir, Y Ben Shaul; The effect of sodium hyaluronate on the corneal epithelium. An ultrastructural study.. Invest. Ophthalmol. Vis. Sci. 1988;29(2):194-199.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The effect of sodium hyaluronate (NaHa) 1% and 0.1% was studied on 14-day chick embryo corneal epithelium by scanning electron microscopy. It was found that NaHa 1% or 0.1% had no toxic effects on the chick corneal epithelium and the normal architecture of the cells and the morphology of the microvilli was well preserved. A combination of NaHa 0.1% and benzalkonium chloride (BAK) 0.01% reduced the toxic effect of BAK on the surface corneal epithelium. NaHa 0.1% provided a better protection of the corneal epithelium against dryness than hydroxyethylcellulose (HEC) 0.1% or phosphate buffer saline (PBS).

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