January 1989
Volume 30, Issue 1
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Articles  |   January 1989
Effect of alpha-1 and beta agonists on contraction of bovine retinal resistance arteries in vitro.
Author Affiliations
  • A M Hoste
    Department of Ophthalmology, University of Ghent, Belgium.
  • P J Boels
    Department of Ophthalmology, University of Ghent, Belgium.
  • D L Brutsaert
    Department of Ophthalmology, University of Ghent, Belgium.
  • J J De Laey
    Department of Ophthalmology, University of Ghent, Belgium.
Investigative Ophthalmology & Visual Science January 1989, Vol.30, 44-50. doi:
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    • Get Citation

      A M Hoste, P J Boels, D L Brutsaert, J J De Laey; Effect of alpha-1 and beta agonists on contraction of bovine retinal resistance arteries in vitro.. Invest. Ophthalmol. Vis. Sci. 1989;30(1):44-50.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Contractile responses of bovine retinal arteries (BRA) (diameter: 179 +/- 9 micron, n = 25) to high K+, circumferential stretch and adrenergic stimulation were studied in vitro. BRA could be activated by rapid circumferential stretch. Under resting conditions, phenylephrine consistently activated BRA at the highest dose of the drug used (10(-5) M). During K+- and stretch-induced activation, significant contractile responses to phenylephrine appeared at lower doses (respectively, 3.10(-8) and 10(-6) M). Isoproterenol did not relax K+- and stretch-induced contractions. Therefore, (1) BRA probably can autoregulate through a myogenic mechanism on the basis of stretch; (2) during alpha 1 adrenergic stimulation, myogenic autoregulatory responses probably increase; (3) contractile responses to alpha 1 adrenergic stimulation are masked under resting conditions; and (4) BRA may not possess functional beta adrenergic receptors.

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