October 1989
Volume 30, Issue 10
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Articles  |   October 1989
Standard models of corneal injury using alkali-immersed filter discs.
Author Affiliations
  • L D Ormerod
    Eye Research Institute of Retina Foundation, Harvard Medical School, Boston, Massachusetts.
  • M B Abelson
    Eye Research Institute of Retina Foundation, Harvard Medical School, Boston, Massachusetts.
  • K R Kenyon
    Eye Research Institute of Retina Foundation, Harvard Medical School, Boston, Massachusetts.
Investigative Ophthalmology & Visual Science October 1989, Vol.30, 2148-2153. doi:
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      L D Ormerod, M B Abelson, K R Kenyon; Standard models of corneal injury using alkali-immersed filter discs.. Invest. Ophthalmol. Vis. Sci. 1989;30(10):2148-2153.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Central corneal alkali burn injuries were induced in rabbits by applying five NaOH concentrations on uniformly soaked 7 mm filter paper discs. Clinical parameters were evaluated daily by microscopic examination and photography, and corneal myeloperoxidase levels were measured periodically. Satisfactory alkali burn models of corneal inflammation, vascularization and ulceration were developed by manipulating the alkali concentration.

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