October 1989
Volume 30, Issue 10
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Articles  |   October 1989
Endothelial cell-stimulating angiogenesis factor in vitreous from extraretinal neovascularizations.
Author Affiliations
  • C M Taylor
    Wolfson Angiogenesis Unit, Hope Hospital, Salford, England.
  • R D Kissun
    Wolfson Angiogenesis Unit, Hope Hospital, Salford, England.
  • A M Schor
    Wolfson Angiogenesis Unit, Hope Hospital, Salford, England.
  • D McLeod
    Wolfson Angiogenesis Unit, Hope Hospital, Salford, England.
  • A Garner
    Wolfson Angiogenesis Unit, Hope Hospital, Salford, England.
  • J B Weiss
    Wolfson Angiogenesis Unit, Hope Hospital, Salford, England.
Investigative Ophthalmology & Visual Science October 1989, Vol.30, 2174-2178. doi:
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    • Get Citation

      C M Taylor, R D Kissun, A M Schor, D McLeod, A Garner, J B Weiss; Endothelial cell-stimulating angiogenesis factor in vitreous from extraretinal neovascularizations.. Invest. Ophthalmol. Vis. Sci. 1989;30(10):2174-2178.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The presence of endothelial cell-stimulating angiogenic factor (ESAF) in diseased human vitreous humour has been established. The molecular mass and chromatographic behavior of this material and its property of activating procollagenase indicate it to be identical to the ESAF isolated from other sources. The biological activity of ESAF from human vitreous was demonstrated by its ability to induce positive responses in the rabbit corneal pocket, and in the chick chorioallantoic membrane and yolk sac membrane tests.

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