February 1988
Volume 29, Issue 2
Free
Articles  |   February 1988
Effects of neuropeptide Y on the isolated rabbit iris dilator muscle.
Author Affiliations
  • M Piccone
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia 19104.
  • J Littzi
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia 19104.
  • T Krupin
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia 19104.
  • R A Stone
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia 19104.
  • M Davis
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia 19104.
  • M B Wax
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia 19104.
Investigative Ophthalmology & Visual Science February 1988, Vol.29, 330-332. doi:
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    • Get Citation

      M Piccone, J Littzi, T Krupin, R A Stone, M Davis, M B Wax; Effects of neuropeptide Y on the isolated rabbit iris dilator muscle.. Invest. Ophthalmol. Vis. Sci. 1988;29(2):330-332.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The effects of neuropeptide Y (NPY) were studied on an in vitro preparation of rabbit iris dilator muscle. NPY by itself (10(-11) M to 10(-6) M) had no effect on the resting tension or on the maximal electrically-induced response (MER) of the dilator. Phenylephrine (10(-9) M to 10(-4) M) caused a dose-dependent contraction of the dilator muscle (7.8% to 40.6% of the MER). The addition of NPY 10(-6) M enhanced the phenylephrine-induced muscle contraction (8.8% to 76.8% of the MER) without altering the EC50 value (5 X 10(-6) M) of the phenylephrine dose-response curve. These findings support a modulatory role for NPY on the iris dilator muscle.

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