June 1989
Volume 30, Issue 6
Free
Articles  |   June 1989
Retinal damage in macaque after white light exposures lasting ten minutes to twelve hours.
Author Affiliations
  • J J Kremers
    TNO Institute for Perception, Soesterberg, The Netherlands.
  • D van Norren
    TNO Institute for Perception, Soesterberg, The Netherlands.
Investigative Ophthalmology & Visual Science June 1989, Vol.30, 1032-1040. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J J Kremers, D van Norren; Retinal damage in macaque after white light exposures lasting ten minutes to twelve hours.. Invest. Ophthalmol. Vis. Sci. 1989;30(6):1032-1040.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

We induced photochemical damage in small parts of the retinas of anesthetized macaques after light exposures of varying intensity, lasting between 10 min and 12 hr. Damage was assessed both with funduscopy and densitometry at several periods after exposure. Damage was most extensive 2 days post-exposure, with similar thresholds for both methods. Reciprocity between exposure time and irradiance was found for all exposures at a threshold irradiant dose of 230 J/cm2. This is in good agreement with part of the literature data on monkeys, yet contradicts another report (Sykes et al) in which a much lower threshold dose was found. The latter data probably concern a different class of damage. It remains unclear what critical factors distinguish the two classes. Observations more than 70 days post-exposure show a divergence between funduscopic and densitometric thresholds. Although the appearance of funduscopic lesions had changed, the threshold dose remained 230 J/cm2. Densitometry showed full recovery of the amount of visual pigment for doses below 600 J/cm2.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×