July 1989
Volume 30, Issue 7
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Articles  |   July 1989
Herpes simplex retinitis in the mouse. Clinicopathologic correlations.
Author Affiliations
  • S W Cousins
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101.
  • A Gonzalez
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101.
  • S S Atherton
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101.
Investigative Ophthalmology & Visual Science July 1989, Vol.30, 1485-1494. doi:
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      S W Cousins, A Gonzalez, S S Atherton; Herpes simplex retinitis in the mouse. Clinicopathologic correlations.. Invest. Ophthalmol. Vis. Sci. 1989;30(7):1485-1494.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

BALB/c mice inoculated with herpes simplex virus type 1 in one anterior chamber develop retinitis with subsequent retinal necrosis in the contralateral eye. The clinical features of this disease were characterized with indirect ophthalmoscopy and fundus photography. Three phases of the disease were delineated: (1) acute retinitis; (2) retinal necrosis; and (3) resolution; the clinical findings in each phase were correlated with the microscopic features. In addition, we compared the virus titers from individual animals with and without clinical evidence of retinitis to demonstrate that retinal inflammation correlated with the titer of virus in the uninoculated eye. This animal model is useful for the analysis of the clinical, virologic and immunologic manifestations of herpetic retinitis.

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