June 1989
Volume 30, Issue 6
Free
Articles  |   June 1989
Effect of topical timolol maleate on the ophthalmic artery blood pressure.
Author Affiliations
  • J E Grunwald
    Scheie Eye Institute, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia 19104.
  • C Furubayashi
    Scheie Eye Institute, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia 19104.
Investigative Ophthalmology & Visual Science June 1989, Vol.30, 1095-1100. doi:
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      J E Grunwald, C Furubayashi; Effect of topical timolol maleate on the ophthalmic artery blood pressure.. Invest. Ophthalmol. Vis. Sci. 1989;30(6):1095-1100.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The effects of topical timolol maleate 0.5% on the ophthalmic artery diastolic (OABPd), systolic (OABPs) and mean blood pressure (OABPm) were investigated in 19 healthy subjects using compression ophthalmodynamometry. In a randomized, double-blind study, one eye of each subject received one drop of timolol maleate 0.5% and the fellow eye received a drop of placebo. Measurements of OABPd and OABPs were performed just prior to instillation of the drops, and then 2 hr later. OABPm was calculated as OABPm = OABPd + 1/3 (OABPs - OABPd). No significant changes in OABPd, OABPs or OABPm were observed following the drops in the timolol-treated eyes or in the placebo-treated eyes. A significant difference (P = 0.0198) was found, however, when the changes in OABPm occurring in the timolol-treated eyes were compared with the changes occurring in the placebo-treated eyes, suggesting that the drug may have an effect upon ophthalmic artery pressure and retinal artery pressure that is expressed differently in each eye.

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