June 1989
Volume 30, Issue 6
Free
Articles  |   June 1989
Platelet-activating factor and laser trauma of the iris.
Author Affiliations
  • N L Verbey
    Eye Hospital, Rotterdam, The Netherlands.
  • J L Van Delft
    Eye Hospital, Rotterdam, The Netherlands.
  • N J Van Haeringen
    Eye Hospital, Rotterdam, The Netherlands.
  • P Braquet
    Eye Hospital, Rotterdam, The Netherlands.
Investigative Ophthalmology & Visual Science June 1989, Vol.30, 1101-1103. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      N L Verbey, J L Van Delft, N J Van Haeringen, P Braquet; Platelet-activating factor and laser trauma of the iris.. Invest. Ophthalmol. Vis. Sci. 1989;30(6):1101-1103.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Local application of platelet-activating factor (PAF) on the rabbit eye caused a dose-dependent significant increase in intraocular pressure (IOP). After laser irradiation of the iris the IOP showed a hypertensive phase of about 3 hr. Prophylactic treatment with the PAF antagonist BN 52021 but not with indomethacin abolished the hypertensive phase. Elevated levels of protein (10.6 +/- 0.9 g/l) and prostaglandin E2 (PGE2, 1.7 +/- 0.2 ng/ml) were measured in the aqueous humor 2 hr after laser irradiation of the iris. Prophylactic treatment with BN 52021 showed lower levels of protein (6.1 +/- 0.7) and PGE2 (1.1 +/- 0.02); with indomethacin pretreatment the level of protein was 3.4 +/- 0.7 g/l and of PGE2 0.10 +/- 0.02 ng/ml. A role of PAF as a mediator in ocular inflammatory response is suggested.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×