May 1989
Volume 30, Issue 5
Free
Articles  |   May 1989
The effects of ultrasonically induced hyperthermia on experimental tumors in the rabbit eye.
Author Affiliations
  • R Braakman
    Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
  • P van der Valk
    Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
  • J L van Delft
    Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
  • D de Wolff-Rouendaal
    Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
  • J A Oosterhuis
    Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
Investigative Ophthalmology & Visual Science May 1989, Vol.30, 835-844. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R Braakman, P van der Valk, J L van Delft, D de Wolff-Rouendaal, J A Oosterhuis; The effects of ultrasonically induced hyperthermia on experimental tumors in the rabbit eye.. Invest. Ophthalmol. Vis. Sci. 1989;30(5):835-844.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Greene's melanomas, implanted in the anterior chamber of 31 eyes of 19 Dutch rabbits, were treated with hyperthermia induced by high intensity focused ultrasound (HIFU). The percentage necrosis 24 hr after treatment (N) as a function of steady-state intratumor temperature (T) could be described with N(T) = -181.5 + 4.7T (P less than 0.05). The most frequent side effect was a local hemorrhagic keratitis. The acoustic absorption coefficient and thermal conductivity of the tumor tissue were 0.08 cm-1 X MHz-1 at 36 degrees C and 0.011 W, cm-1 X degrees C-1, respectively. With these parameters a simple thermal model was established that enabled us to predict the ultrasonic intensity needed to reach a desired intratumor temperature.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×