August 1989
Volume 30, Issue 8
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Articles  |   August 1989
The blood-retinal barrier in chloroquine retinopathy.
Author Affiliations
  • M F Raines
    Manchester Royal Eye Hospital, England.
  • S K Bhargava
    Manchester Royal Eye Hospital, England.
  • E S Rosen
    Manchester Royal Eye Hospital, England.
Investigative Ophthalmology & Visual Science August 1989, Vol.30, 1726-1731. doi:
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      M F Raines, S K Bhargava, E S Rosen; The blood-retinal barrier in chloroquine retinopathy.. Invest. Ophthalmol. Vis. Sci. 1989;30(8):1726-1731.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Chloroquine retinopathy can result in devastating loss of vision. To date, there are no effective and reliable methods of detecting the toxicity at an early stage when retinopathy may be reversible. Chloroquine is deposited in the retinal pigment epithelium, which forms part of the blood-retinal barrier (BRB). By vitreous fluorophotometry we have shown that there is breakdown of the BRB in chloroquine retinopathy. However, in asymptomatic patients who had received varying amounts of hydroxychloroquine (up to 1067 g), the BRB remained intact.

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