August 1989
Volume 30, Issue 8
Free
Articles  |   August 1989
S (blue) cone pathway vulnerability in retinitis pigmentosa, diabetes and glaucoma.
Author Affiliations
  • V C Greenstein
    Department of Ophthalmology, New York University, Medical Center, New York 10016.
  • D C Hood
    Department of Ophthalmology, New York University, Medical Center, New York 10016.
  • R Ritch
    Department of Ophthalmology, New York University, Medical Center, New York 10016.
  • D Steinberger
    Department of Ophthalmology, New York University, Medical Center, New York 10016.
  • R E Carr
    Department of Ophthalmology, New York University, Medical Center, New York 10016.
Investigative Ophthalmology & Visual Science August 1989, Vol.30, 1732-1737. doi:
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    • Get Citation

      V C Greenstein, D C Hood, R Ritch, D Steinberger, R E Carr; S (blue) cone pathway vulnerability in retinitis pigmentosa, diabetes and glaucoma.. Invest. Ophthalmol. Vis. Sci. 1989;30(8):1732-1737.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A variety of retinal disease lead to a decrease in the sensitivity of the S (blue) cone pathways. To determine the possible sites and mechanisms of this loss we compared the sensitivities of an S (blue/pi-1) and an M (green/pi-4) cone pathway in patients with retinal diseases that differ as to their primary locus of sensitivity loss. The sensitivities of an S and an M cone pathway were assessed in patients with retinitis pigmentosa, insulin-dependent diabetes mellitus and open-angle glaucoma using Stiles two-color increment threshold technique. A greater loss in sensitivity of an S than an M cone pathway was found for all three disease groups; however, the diabetic patients showed a more selective loss. The results suggest that multiple sites are involved and that the combined effects of metabolic abnormalities and hypoxia contribute to the selective loss.

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