August 1989
Volume 30, Issue 8
Free
Articles  |   August 1989
Presence of epidermal growth factor in human tears.
Author Affiliations
  • Y Ohashi
    Division of Ophthalmology, Kansai Rosai Hospital, Hyogo, Japan.
  • M Motokura
    Division of Ophthalmology, Kansai Rosai Hospital, Hyogo, Japan.
  • Y Kinoshita
    Division of Ophthalmology, Kansai Rosai Hospital, Hyogo, Japan.
  • T Mano
    Division of Ophthalmology, Kansai Rosai Hospital, Hyogo, Japan.
  • H Watanabe
    Division of Ophthalmology, Kansai Rosai Hospital, Hyogo, Japan.
  • S Kinoshita
    Division of Ophthalmology, Kansai Rosai Hospital, Hyogo, Japan.
  • R Manabe
    Division of Ophthalmology, Kansai Rosai Hospital, Hyogo, Japan.
  • K Oshiden
    Division of Ophthalmology, Kansai Rosai Hospital, Hyogo, Japan.
  • C Yanaihara
    Division of Ophthalmology, Kansai Rosai Hospital, Hyogo, Japan.
Investigative Ophthalmology & Visual Science August 1989, Vol.30, 1879-1882. doi:
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      Y Ohashi, M Motokura, Y Kinoshita, T Mano, H Watanabe, S Kinoshita, R Manabe, K Oshiden, C Yanaihara; Presence of epidermal growth factor in human tears.. Invest. Ophthalmol. Vis. Sci. 1989;30(8):1879-1882.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Epidermal growth factor (EGF) is a polypeptide that stimulates the growth of various tissues, including the cornea. The presence of EGF in tears from normal volunteers and in aqueous humor from cataract patients was investigated via human EGF (hEGF)-specific radioimmunoassay. Immunoreactive hEGF was found to be present at similar concentrations in both reflex (ranging from 0.7 to 8.1 ng/ml) and non-reflex tears (ranging from 1.9 to 9.7 ng/ml), but was undetectable in aqueous humor. Immunoreactive EGF in human tears was indistinguishable immunologically, biologically and biochemically from urine EGF and standard hEGF.

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