October 1991
Volume 32, Issue 11
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Articles  |   October 1991
Expression of tenascin and cellular fibronectin in the rabbit cornea after anterior keratectomy. Immunohistochemical study of wound healing dynamics.
K Tervo; G B van Setten; R W Beuerman; I Virtanen; A Tarkkanen; T Tervo
Author Affiliations
  • K Tervo
    Department of Anatomy, University of Helsinki, Finland.
  • G B van Setten
    Department of Anatomy, University of Helsinki, Finland.
  • R W Beuerman
    Department of Anatomy, University of Helsinki, Finland.
  • I Virtanen
    Department of Anatomy, University of Helsinki, Finland.
  • A Tarkkanen
    Department of Anatomy, University of Helsinki, Finland.
  • T Tervo
    Department of Anatomy, University of Helsinki, Finland.
Investigative Ophthalmology & Visual Science October 1991, Vol.32, 2912-2918. doi:
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      K Tervo, G B van Setten, R W Beuerman, I Virtanen, A Tarkkanen, T Tervo; Expression of tenascin and cellular fibronectin in the rabbit cornea after anterior keratectomy. Immunohistochemical study of wound healing dynamics.. Invest. Ophthalmol. Vis. Sci. 1991;32(11):2912-2918.

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Abstract

Anterior keratectomy (AKE) was done on rabbits, and the appearance of immunohistochemically demonstrable tenascin (TN) or cellular fibronectin (cFN) was studied at different times (5 min to 14 months) after the operation. The substance TN was first observed 12 hr after wounding in the posterior stroma; cFN appeared with the same localization 12 hr later. During postoperative week 1, both TN and cFN immunoreactions shifted to more anterior parts of the cornea, and 9 days after wounding, they were localized in the most anterior part of the stroma only. Thereafter the reactions gradually decreased in intensity but still were visible 3 months after AKE. No reaction for TN or cFN was present 14 months postoperatively.

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