November 1992
Volume 33, Issue 12
Free
Articles  |   November 1992
MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate.
Author Affiliations
  • A M el-Asrar
    Department of Ophthalmology, Mansoura University Hospital, Egypt.
  • P H Morse
    Department of Ophthalmology, Mansoura University Hospital, Egypt.
  • D Maimone
    Department of Ophthalmology, Mansoura University Hospital, Egypt.
  • E Torczynski
    Department of Ophthalmology, Mansoura University Hospital, Egypt.
  • A T Reder
    Department of Ophthalmology, Mansoura University Hospital, Egypt.
Investigative Ophthalmology & Visual Science November 1992, Vol.33, 3463-3468. doi:
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      A M el-Asrar, P H Morse, D Maimone, E Torczynski, A T Reder; MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate.. Invest. Ophthalmol. Vis. Sci. 1992;33(12):3463-3468.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The protective effect of the anticonvulsant MK-801 and the antitussive dextromethorphan, which are both N-methyl-D-aspartate receptor antagonists, and kynurenic acid, a broad-spectrum excitotoxin antagonist, was tested in cultured rat retinal cells in an hypoxic environment. The protective effect of these antagonists also was tested in cultured retinal cells and in intact adult rat retinas exposed to the exogenous excitotoxins L-glutamic acid and N-methyl-D-aspartic acid. MK-801 and kynurenic acid protected retinal neurons from hypoxic damage and from the toxicity of exogenous L-glutamic acid and N-methyl-D-aspartic acid. Dextromethorphan, a less potent antagonist, did not protect the retinal neurons from hypoxic damage or the toxicity of exogenous L-glutamic acid, but did attenuate N-methyl-D-aspartate toxicity. These results provide evidence that the synaptic release of excitatory transmitters, most likely glutamate and aspartate, mediate the death of hypoxic retinal neurons. Compounds related to MK-801 may have possible therapeutic applications in the management of retinal ischemia.

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