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M De La Paz, R E Anderson; Region and age-dependent variation in susceptibility of the human retina to lipid peroxidation.. Invest. Ophthalmol. Vis. Sci. 1992;33(13):3497-3499.
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Trephined buttons from the posterior central (including the macula) and four peripheral regions of human retina were subjected to in vitro lipid peroxidation initiated by Fe+2. There was an age-related increase in peroxidation in the retinal tissue from the posterior region (P = 0.0019), but not in tissues from any of the four peripheral retinal quadrants (collective P = 0.24). These results suggest that the posterior region of the human retina is susceptible to lipid peroxidation and that age is a factor.
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