October 1992
Volume 33, Issue 11
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Articles  |   October 1992
Hyaluronic acid in the rabbit cornea after excimer laser superficial keratectomy.
Author Affiliations
  • T D Fitzsimmons
    Department of Ophthalmology, Karolinska Institutet, S:t Eriks Eye Hospital, Stockholm, Sweden.
  • P Fagerholm
    Department of Ophthalmology, Karolinska Institutet, S:t Eriks Eye Hospital, Stockholm, Sweden.
  • A Härfstrand
    Department of Ophthalmology, Karolinska Institutet, S:t Eriks Eye Hospital, Stockholm, Sweden.
  • M Schenholm
    Department of Ophthalmology, Karolinska Institutet, S:t Eriks Eye Hospital, Stockholm, Sweden.
Investigative Ophthalmology & Visual Science October 1992, Vol.33, 3011-3016. doi:
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    • Get Citation

      T D Fitzsimmons, P Fagerholm, A Härfstrand, M Schenholm; Hyaluronic acid in the rabbit cornea after excimer laser superficial keratectomy.. Invest. Ophthalmol. Vis. Sci. 1992;33(11):3011-3016.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Hyaluronic acid (HA) is not normally found in the corneal stroma. Rabbit corneas were examined for the presence of stromal HA after excimer laser treatment. One eye in each of 28 rabbits received a 60 microns deep superficial keratectomy with the excimer laser. After 1, 8, 21, and 60 days, the corneas were analyzed by quantitative and histochemical methods specific for HA. A statistically significant increase in the HA concentration compared to the baseline amount in the untreated fellow eye was seen at 8, 21, and 60 days. HA was visualized histochemically in the anterior stroma of the excimer-treated eyes at all times tested. The presence of HA after excimer surgery may influence the hydration, thickness, and transparency of the cornea. The reactive production of HA in the stroma may represent a nonspecific corneal tissue response to injury.

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