February 1992
Volume 33, Issue 2
Free
Articles  |   February 1992
The large-conductance potassium ion channel of rabbit corneal epithelium is blocked by quinidine.
Author Affiliations
  • J L Rae
    Department of Physiology, Mayo Foundation, Rochester, Minnesota 55905.
  • J Dewey
    Department of Physiology, Mayo Foundation, Rochester, Minnesota 55905.
  • J S Rae
    Department of Physiology, Mayo Foundation, Rochester, Minnesota 55905.
Investigative Ophthalmology & Visual Science February 1992, Vol.33, 286-290. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J L Rae, J Dewey, J S Rae; The large-conductance potassium ion channel of rabbit corneal epithelium is blocked by quinidine.. Invest. Ophthalmol. Vis. Sci. 1992;33(2):286-290.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Basal layers of the rabbit corneal epithelium contain a large-conductance potassium ion (K+) selective channel (160-170 pS in 150 mM KCl). This channel previously was shown to be blocked by cesium and barium ions applied to its outer surface. By direct patch clamp experiments, it is shown that the channel also is blocked by quinidine in the 0.1-1 mM range when applied either to the outside or inside of membrane patches containing these channels. This additional pharmacologic tool should aid in identifying the individual currents that compose the macroscopic currents from corneal epithelial cells and eventually should help to provide a detailed assessment of their function.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×