November 1992
Volume 33, Issue 12
Free
Articles  |   November 1992
Radial keratotomy. III. Relationship between wound gape and corneal curvature in primate eyes.
Author Affiliations
  • W M Petroll
    Center for Sight, Georgetown University Medical Center, Washington, DC.
  • K New
    Center for Sight, Georgetown University Medical Center, Washington, DC.
  • M Sachdev
    Center for Sight, Georgetown University Medical Center, Washington, DC.
  • H D Cavanagh
    Center for Sight, Georgetown University Medical Center, Washington, DC.
  • J V Jester
    Center for Sight, Georgetown University Medical Center, Washington, DC.
Investigative Ophthalmology & Visual Science November 1992, Vol.33, 3283-3291. doi:
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      W M Petroll, K New, M Sachdev, H D Cavanagh, J V Jester; Radial keratotomy. III. Relationship between wound gape and corneal curvature in primate eyes.. Invest. Ophthalmol. Vis. Sci. 1992;33(12):3283-3291.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The relationship between changes in wound gape and corneal curvature after radial keratotomy (RK) was evaluated in five primates. Four-incision RK was performed using a diamond knife set to 100% of central corneal thickness with a 3-mm optical zone. In vivo measurements of wound gape were obtained using tandem scanning confocal microscopy at 3, 7, 14, and 45 days after surgery. The changes in corneal contour were measured at the same time points using a corneal modeling system with a specially designed primate cone. Wounds progressively increased in width to a maximum of 38 +/- 1 microns (n = 5) at day 7. After day 7, wounds showed increasing fibrosis which correlated with decreasing wound gape to 20 +/- 1 microns at day 45. A similar temporal change was detected in central corneal curvature (K), with maximum flattening occurring at day 7 (delta K = -3.17 +/- 0.90 diopters, n = 5), and progressive regression of effect to -1.32 +/- 0.61 diopters (n = 5) at day 45. Although there was interanimal variation, the mean temporal changes in corneal curvature significantly paralleled the changes in wound gape (r = -0.96, n = 4, P < 0.05). Based upon these findings, a simple geometric model was proposed which provides a hypothetic foundation for the relationship between corneal curvature and wound gape after RK. Calculations of wound gape made from this analytic model (using the measured topographic data) showed significant correlation with the actual wound gape measurements (r = 0.96, n = 4, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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