October 1992
Volume 33, Issue 11
Free
Articles  |   October 1992
Biodegradable microspheres containing adriamycin in the treatment of proliferative vitreoretinopathy.
Author Affiliations
  • T Moritera
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • Y Ogura
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • N Yoshimura
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • Y Honda
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • R Wada
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • S H Hyon
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • Y Ikada
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Investigative Ophthalmology & Visual Science October 1992, Vol.33, 3125-3130. doi:
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    • Get Citation

      T Moritera, Y Ogura, N Yoshimura, Y Honda, R Wada, S H Hyon, Y Ikada; Biodegradable microspheres containing adriamycin in the treatment of proliferative vitreoretinopathy.. Invest. Ophthalmol. Vis. Sci. 1992;33(11):3125-3130.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The use of biodegradable polymer microspheres containing adriamycin for the treatment of proliferative vitreoretinopathy (PVR) in an experimental rabbit model was investigated. A single injection of microspheres containing 10 micrograms of adriamycin effectively decreased traction retinal detachment to 10% (n = 10), whereas 50% of eyes injected with blank microspheres (n = 10) developed retinal detachment (P < 0.05). A single injection of microspheres, containing 3 micrograms of adriamycin, did not suppress retinal detachment. Electroretinographic and histologic studies confirmed that the 10 micrograms injection of adriamycin in microspheres was not toxic to the retina, although the injection of the same amount of free adriamycin caused retinal necrosis and detachment. Thus, microspheres containing adriamycin hold promise as a new treatment modality for PVR.

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