October 1992
Volume 33, Issue 11
Free
Articles  |   October 1992
Effect of acute increases in intraocular pressure on intravascular optic nerve head oxygen tension in cats.
Author Affiliations
  • R D Shonat
    Department of Ophthalmology, Scheie Eye Institute, Philadelphia, PA 19104.
  • D F Wilson
    Department of Ophthalmology, Scheie Eye Institute, Philadelphia, PA 19104.
  • C E Riva
    Department of Ophthalmology, Scheie Eye Institute, Philadelphia, PA 19104.
  • S D Cranstoun
    Department of Ophthalmology, Scheie Eye Institute, Philadelphia, PA 19104.
Investigative Ophthalmology & Visual Science October 1992, Vol.33, 3174-3180. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R D Shonat, D F Wilson, C E Riva, S D Cranstoun; Effect of acute increases in intraocular pressure on intravascular optic nerve head oxygen tension in cats.. Invest. Ophthalmol. Vis. Sci. 1992;33(11):3174-3180.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

A newly developed phosphorescence imaging technique was used to generate two-dimensional maps of intravascular oxygen tension (PO2) in the optic nerve head (ONH) and retina of the cat to study the effects of acute moderate increases in intraocular pressure (IOP) on the ONH and retinal PO2. Both the ONH and retinal PO2 were remarkably well maintained as the IOP increased; hypoxia developed only after the blood flow to the eye was stopped. Because ONH hypoxia was not observed during IOP elevation, a lack of oxygen may not be a major cause of glaucomatous damage, although the effects of chronically elevated IOP on the PO2 remain to be evaluated. Because this imaging technique was noninvasive and required only a small bolus injection of a nontoxic oxygen probe, the authors anticipate that it will find significant application in the study of many ocular vascular diseases and glaucoma.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×