June 1991
Volume 32, Issue 7
Free
Articles  |   June 1991
Effect of fibronectin on corneal epithelial wound healing in the vitamin A-deficient rat.
Author Affiliations
  • K Watanabe
    Cornea Unit, Eye Research Institute, Boston, MA 02114.
  • G Frangieh
    Cornea Unit, Eye Research Institute, Boston, MA 02114.
  • C V Reddy
    Cornea Unit, Eye Research Institute, Boston, MA 02114.
  • K R Kenyon
    Cornea Unit, Eye Research Institute, Boston, MA 02114.
Investigative Ophthalmology & Visual Science June 1991, Vol.32, 2159-2162. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      K Watanabe, G Frangieh, C V Reddy, K R Kenyon; Effect of fibronectin on corneal epithelial wound healing in the vitamin A-deficient rat.. Invest. Ophthalmol. Vis. Sci. 1991;32(7):2159-2162.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
This content is PDF only. Please click on the PDF icon to access.
Abstract

The authors investigated the in vitro and in vivo effects of fibronectin (Fn) on the migration of corneal epithelium of vitamin A-deficient (A-) and pair-fed control (A+) rats. Groups treated with 50 micrograms/ml Fn showed accelerated healing of epithelium in vitro (P less than 0.05) compared with control groups of A- and A+ rats. However, when 100 micrograms/ml Fn eye drops were administered 14 times over 20 hr, they had no significant effect on A+ rats in vivo, but increased the healing in A- rats (P less than 0.05). In this model, Fn promoted the healing of corneal epithelium under A- conditions where decreased endogenous Fn is seen, whereas A+ corneas in vivo, which have sufficient Fn over the wound surface, did not benefit from topical Fn administration.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×